Tissue/organ-specialized immunologic features and disease mechanisms

Immunology is a pioneer and practical discipline in biomedical science,bridging basic biologic knowledge with clinical medicine,so called core of translational medicine.Recently,it was noted that the immunologic parameters from blood and bone marrow greatly differ in those not only from mucosal immune system including gastrointestinal tract,respiratory tract and urogenital tract but also from the non-immune organs such as liver,pancreas,bone,uterine,kidney,and so on.These mucosal immunologic and "unprofessional immune" tissue/organs are characterized with their own anatomy,microenvironment,immune cell population and subsets with unique functional molecules,forming unique regional immune features which dominantly control the disease process related to each tissue/organ.At present,there are few studies to explore the relationship of "unprofessional immune" tissue/organs to disease mechanisms,to professional immune tissue/organs,to circulating immune system.The frontier research on tissue/organ-specialized immune features and their molecular and cellular mechanisms will greatly improve to deep elucidate the relation of regional immunity to major diseases and to extensively discover novel immunotherapeutic targets.So,tissue/organ-specialized immunology is leading the immunologic study and is in keep with national requirement.