Ultrasound-accelerated green synthesis of new quinolin-2-thione derivatives and antimicrobial evaluation against Escherichia coli and Staphylococcus aureus
2020
Abstract An efficient, green strategy to access to a new series of quinolinthiones was investigated. The targeted derivatives have been prepared from arylhydrazides and 2-thiocoumarin under ultrasound irradiation in refluxing water. The remarkable features of this strategy are simple procedure, high conversion, cleaner with short reaction times. All resultant compounds were screened against bacterial strains for in vitro anti-bacterial activity. Derivative (6b) was showed highest potency with 22 and 24 mm inhibition zone against Staphylococcus aureus (Sa) and Escherichia coli (Ec), respectively.
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