Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice

Miranda M.C. van Beers,Melody Sauerborn,F. Gilli,Vera Brinks,Huub Schellekens,Wim Jiskoot

Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice

2011

Miranda M.C. van Beers
Melody Sauerborn
F. Gilli
Vera Brinks
Huub Schellekens
Wim Jiskoot

Purpose To study the effect of oxidation on the structure of recombinant human interferon beta-1a (rhIFNβ-1a) and its immunogenicity in wild-type and immune-tolerant transgenic mice.

Keywords:

Antibody
Immunogenicity
Plasma protein binding
Interferon
Protein aggregation
Virology
Genetically modified mouse
Molecular biology
Recombinant DNA
Immune tolerance
Chemistry

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