4,5‐Disubstituted‐1,3‐oxazolidin‐2‐imine Derivatives: A New Class of Orally Bioavailable Nitric Oxide Synthase Inhibitor.

In our search for a novel class of inducible nitric oxide synthase (iNOS) inhibitors, 1,3-oxazolidin-2-imine was found to weakly inhibit iNOS. Further modifications of this compound resulted in a remarkable increase in both the in vivo and in vitro inhibitory activity and selectivity for iNOS.