Palmitoylethanolamide Relieves Pain and Preserves Pancreatic Islet Cells in a Murine Model of Diabetes
2015
We previously demonstrated that the intraperitoneal administration of palmitoylethanolamide
(PEA) in mice with chronic constriction injury of the sciatic nerve evoked a relief of both
thermal hyperalgesia and mechanical allodynia in neuropathic mice. Since diabetic neuropathy is one
of the most common long-term complications of diabetes, we explored the ability of PEA to also relief
this kind of chronic pain, employing the well established streptozotocin-induced animal model of type
1 diabetes. Our findings demonstrated that PEA relieves mechanical allodynia, counteracts nerve
growth factor deficit, improves insulin level, preserves Langherans islet morphology reducing the
development of insulitis in diabetic mice. These results suggest that PEA could be effective in type1 -diabetic patients not
only as pain reliever but also in controlling the development of pathology.
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