Effect of Neoplastic Tissue on the Turnover of Liver Nucleic Acids

The rate of incorporation of P32 into DNA, nuclear PNA, and cytoplasmic PNA of liver tissue was measured in male A strain mice bearing transplanted mammary carcinoma, in female A strain mice bearing transplanted sarcoma A274, and in female C57 strain mice bearing a transplanted mammary carcinoma. An increase of P32 incorporation into the liver DNA was noted in all three groups of tumor-bearing mice when compared to the controls. A decrease in P32 incorporation into nuclear PNA was observed in the male A strain mice bearing mammary carcinoma. No significant difference in the rate of incorporation of P32 into the cytoplasmic PNA was observed in the tumor-bearing mice.