Comparison of Location of Culprit Lesions in Left Anterior Descending Coronary Artery Among Patients With Anterior Wall ST-Segment Elevation Myocardial Infarction Having Ramus Intermedius Coronary Arteries Versus Patients Not Having Such Arteries

Disturbed, nonlaminar flow distal to arterial bifurcations contributes to atherosclerosis development and progression. We hypothesized that the presence of a ramus intermedius (RI) amplifies the flow disturbances in the proximal left anterior descending (LAD) artery causing more proximal LAD lesions and larger ST-segment elevation myocardial infarction (STEMI). Emory University's contribution to the National Cardiovascular Data Registry was queried for STEMIs from January 2006 to July 2008. The distance from the LAD ostium to the lesion was measured in patients with angiographically visible culprit lesions. The peak troponin-I, creatinine kinase-MB, and left ventricular ejection fraction were used as markers for infarct size. Of the 386 patients with STEMI, 150 had LAD culprit lesions. The mean lesion distance from the LAD ostium was 15.2 ± 11.0 mm in the patients with RI (n = 44) and 29 ± 19 mm in those without RI (n = 106; p