Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance

Zhi Shi,Amit K. Tiwari,Suneet Shukla,Robert W. Robey,Satyakam Singh,In Wha Kim,Susan E. Bates,Xing Xiang Peng,Ioana Abraham,Suresh V. Ambudkar,Tanaji T. Talele,Li Wu Fu,Zhe-Sheng Chen

Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance

2011

Zhi Shi
Amit K. Tiwari
Suneet Shukla
Robert W. Robey
Satyakam Singh
In Wha Kim
Susan E. Bates
Xing Xiang Peng
Ioana Abraham
Suresh V. Ambudkar
Tanaji T. Talele
Li Wu Fu
Zhe-Sheng Chen

A drug used widely to treat erectile dysfunction in men is found to abrogate two common mechanisms of chemotherapeutic drug resistance, with immediate potential applications to improve the treatment of many advanced cancers.

Keywords:

Sildenafil
Drug
Drug resistance
Multidrug Resistance-Associated Proteins
Erectile dysfunction
Phosphodiesterase 5 inhibitor
Paclitaxel
Pharmacology
Methotrexate
Medicine
Phosphodiesterase inhibitor

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