Comparing cervical maturation in preterm and term birth mouse models with Raman spectroscopy (Conference Presentation)

Preterm birth (PTB), when defined as labor before 37 weeks of gestation, affects approximately 1 out of every 10 births in the United States, leading to high rates of mortality. Complete understanding of the mechanism of PTB requires non-invasive, multi-modal techniques that can provide information about the cascade of labor onset. This study compares the cervical remodeling in wild-type term and induced preterm mouse models using Raman spectroscopy. This study demonstrates the potential of Raman spectroscopy as a non-invasive, real-time in-vivo modality to understand cervix remodeling, thus guiding future studies to improve reproductive and neonatal outcomes.