An Efficient Stereoselective Total Synthesis of Bioactive (3R,5R)-1-(4-Hydroxyphenyl)-7-phenylheptane-3,5-diol via Asymmetric Aldol Reaction
2016
An efficient stereoselective total synthesis of (3R,5R)-1-(4-hydroxyphenyl)-7-phenylheptane-3,5-diol (1) is reported based on the Mukaiyama aldol reaction. The total synthesis of compound 1 was accomplished with 30% overall yield in simple eight steps from commercially available trans-cinnamaldehyde.
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