Intervention Mechanism of Traditional Chinese Medicine on Corona Virus Disease 2019(COVID-19) Based on RAS Axes/ 基于RAS双轴探讨中药对新型冠状病毒肺炎的干预机制

It is to explore the lung injury of corona virus disease 2019 (COVID-19) and the relationship between multiple organs damage and renin-angiotensin system (RAS) axes ACE/AngⅡ/AT1R and ACE2/Ang (1-7)/Mas It is suggested that angiotensin converting enzyme 2 (ACE2) may play a dual role in mediating susceptibility and immunity of SARS-CoV-2 infection In view of the dilemma of ACE2 targeted therapy, angiotensin type 2 receptor (AT2R) and Ang (1-7)/Mas receptor may be proposed as targets for traditional Chinese medicine (TCM) intervention Based on the RAS axes downstream signaling pathway, the possible intervention mechanism of TCM for COVID-19 was explored It is proved that the location is mainly the lung, involving spleen，stomach kidney and vessels because the high expression of ACE2 in the lungs，stomach and intestines，kidneys and vascular epithelium cells The main treatment principles are clearing lung，strengthening spleen，purging the turbid and resolving blood stasis