Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies Peroxisome Proliferator-Activated Receptor Gamma as an intrinsic negative regulator of viral replication

Annie Bernier,Aurélie Cleret-Buhot,Yuwei Zhang,Jean-Philippe Goulet,Patricia Monteiro,Annie Gosselin,Sandrina DaFonseca,Vanessa Sue Wacleche,Mohammad-Ali Jenabian,Jean-Pierre Routy,Cécile Tremblay,Petronela Ancuta

Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies Peroxisome Proliferator-Activated Receptor Gamma as an intrinsic negative regulator of viral replication

2013

Annie Bernier
Aurélie Cleret-Buhot
Yuwei Zhang
Jean-Philippe Goulet
Patricia Monteiro
Annie Gosselin
Sandrina DaFonseca
Vanessa Sue Wacleche
Mohammad-Ali Jenabian
Jean-Pierre Routy
Cécile Tremblay
Petronela Ancuta

Background We previously demonstrated that primary Th1Th17 cells are highly permissive to HIV-1, whereas Th1 cells are relatively resistant. Molecular mechanisms underlying these differences remain unknown.

Keywords:

Viral replication
Gene expression profiling
Permissiveness
Virology
Peroxisome proliferator-activated receptor
Real-time polymerase chain reaction
Regulator
Flow cytometry
Permissive
Biology
Antibody
Protein structure
human immunodeficiency virus
negative regulator

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