Effect of cholesterol vehicle in experimental atherosclerosis.

ginmming of timis cemmtmmrythat cholesterol feeding of rabbits led to atimeronmata, a large ntmmber of chmolesterol-feed!ing experiments have been carried oumt. In these experiments timis sterol was usually administered! in an oil (fat) suspension, but comparison of different types of fat was not cairied out. About 15 years ago we began to compare the effect of the cholesterol vehicle upon cisolesterol-induced atherosclerosis. In the first of these experiments, cholesterol was ad!dedl dlirectly to time rabbit chow or was fed together with a partially saturated fat (vegetable shortening; iodine value, 72) or a hmighmly unsaturated fat (cormm oil; iodine value, 130). We observed that the diet containing cholesterol plus corn oil was considerably less atherogenic tlman that containing shortening (1). Time shortening cholesterol regimen was slightly less atheu-ogenic tisan was tise dhet containing no fat. A second! experiment showed that time degree of saturation of time fat did indeed! play a role in cholesterol-indumced atherosclerosis in rabbits. A diet containing cholesterol and methyl stearate (iodine value, 0) was more athmerogenic than one containing methyl oleate (iodine value, 90) and this diet was, in turn, more atimerogenic