THE EXPRESSION OF MATRIX METALLO PROTEINASE-1 (MMP-1)WITH AND WITHOUT TRIAMCINOLONE ACETONIDE INJECTION SUBCONJUNCTIVA IN PROGRESSIVE PRIMARY PTERYGIUM

Background Pathogenesis of the pterygium and the cause of recurrence rate after surgical treatment is still a controversy. One of the pathogenesis theory is the inflammation that may cause the pterygium and influence the recurrences. Matrix metallo proteinase-1 is one part of endopeptidase enzyme which involve the wound healing and remodelling, and it may inhibit the cell damage recovery. Triamcinolone acetonide is an anti inflammatory agent, that has been proposed to limit the expression of MMP-1 in proper situation as its function to heal the wound. Objective To compare the expression of matrix metallo proteinase-1 (MMP-1) with and without triamcinolone acetonide injection subconjunctiva in progressive primary pterygium. Methods A total of 64 eyes from 32 eyes with injection group and 32 eyes without injection group were examined. All specimens were collected. Expression of MMP-1 in two groups was detected using imunohistochemistry. The positive cells were calculated per 100 cells in five different areas. Results The positive expression was stronger and higher in non-injected group than in injected group. The difference was significant (P