Fenetilsulfona isoindoline derivatives as PDE 4 and / or cytokines

A pharmaceutical composition comprising a compound of formula (I): ** ** Formula or a salt, solvate or stereoisomer thereof, wherein: R1 is -C (O) R5, wherein R5 is methyl substituted by - OH; R2 is hydrogen, methyl or glucuronide (gluc); R3 is hydrogen, ethyl or gluc; R4 is hydrogen or hydroxy.