Digit Tip Regeneration and Beyond: Schwann Cell Progenitors to the Rescue

Digit tip regeneration following amputation is an innate response in some mammals, including mice. In this issue of Cell Stem Cell , Johnston et al. (2016) show that Schwann cell precursors are necessary for this process and can rescue regeneration in denervated digit tips through secretion of pro-regenerative factors including OSM and PDGF-AA.