Abstract MP03: All-Cause Mortality and Cardiorespiratory Fitness Among Patients with a Family History of CHD - The FIT Project

BACKGROUND: The extent to which cardiorespiratory fitness (CRF) provides meaningful risk stratification among those with a family history (FH) of coronary heart disease (CHD) is yet to be defined. We compare all-cause mortality in individuals with a FH of CHD to those without. METHODS: We retrospectively studied 68,947 patients without history of CHD (n=7,980) or heart failure (n=1,564) who underwent physician-referred treadmill stress testing between 1991 and 2009. FH of CHD was defined as a self-reported compatible history of CHD in a first-degree relative. CRF was based on peak estimated metabolic equivalents (METS) and categorized into 4 groups: <6, 6 to 10, 10 to 12, and ≥12 METS. Multivariable-adjusted Cox proportional hazards models were used to study the association between increasing METS categories and risk of mortality using the lowest METS category as the reference. Adjusted mortality rates were calculated using direct standardization. Multiplicative interaction testing was performed for FH an...