Identification of a basement membrane proteoglycan in exfoliation material

We have used the indirect immunperoxidase technique to examine the exfoliation syndrome and can demonstrate that the fibrils so typically found in this disease certainly contain basement membrane proteoglycans. This finding is interesting for two reasons: 1. For the first time, an electron-microscopical technique is described that is able to identify one protein component of the exfoliation material. 2. The fact that the basement membrane proteoglycans are present in the exfoliation material supports the hypothesis that this disease is caused by a disturbance in the biosynthesis of the basement membrane.