[Association of cyclic adenosine monophosphate response element-binding protein gene and major depressive disorder].

Objective To investigate the association between single nucleotide polymorphisms (SNPs) in cyclic adenosine monophosphate response element-binding protein (CREB1) gene and major depressive disorder (MDD). Methods We recruited 105 parent-offspring trios of Chinese descent, extracted whole blood genomic DNA, and genotyped the SNPs in rs10932201 and rs6740584 loci. Single-marker transmission disequilibrium test (TDT), pairwise-SNP linkage disequilibrium (LD) and haplotype-based TDT were performed. Results No significant association with MDD was observed for SNPs rs10932201 and rs6740584 (P=0. 1004 and P=0. 4986). However, there was strong positive association between the rs10932201-rs6740584 haplotype and MDD (P = 0. 00003241), and both haplotypes of A-C and A-T were significantly associated with MDD (P = 0. 020 and P = 0. 00022). Conclusion The rs10932201-rs6740584 haplotype of the CREB1 gene may play an important role in the pathogenesis of MDD. Key words: major depressive disorder;  CREB1 gene;  single nucleotide polymorphisms;  haplotype