Formulation and evaluation of fast dissolving tablet of Amlodipine Besylate

In the present work, fast dissolving tablet of Amlodipine besylate was design with a view to and provide a quick onset of action. The main objective of this study was to formulate and evaluate fast dissolving tablets of Amlodipine besylate to achieve a better dissolution rate and further improving the bioavailability of the drug. Fast dissolving tablets prepared by direct compression and using super-disintegrants in different concentration and evaluated for the pre-compression parameters. The prepared tablets were evaluated for post compressional. Among all, the formulation F8 containing 8%w/w super-disintegrant Crosscrarmilose sodium, Crosspovidone and Microcrystalline Cellulose was considered to be best formulation, which release up to 96.50% in 10 min.