Physiological Regulation of Uteroglobin/CCSP Expression

: Uteroglobin/CCSP is expressed specifically in the Clara cells. This allows the gene to be used as a marker to identify the elements regulating the physiologic and cell-specific expression of this gene. The regulation of UG/CCSP by IFN-γ was shown to be at the level of the proximal promoter by the upregulation of HNF3β. This has allowed the determination of the factors responsible for the expression of UG/CCSP.