Progress of Research on the Vector of Capripoxvirus

The diseases of sheep and goat pox and lumpy skin disease of cattle are caused by members of the capripoxvirus.Capripoxvirus,the member of the orthopoxvirus family with the largest genome,probably encodes more genes involved in cell adaptation than any of the other members.Recombinant virus vector is one of the most hot spots in virus gene engineering,there are two vector type,the replaceable recombinant virus vector and the recombinant viral plasmid vector.This review summarized recent advances in the methods of construction of viral transfer plasmid,homologous recombinant,and the activated vaccines derived from the viruses deleted the nonessential gene or inserted with neutralizing gene of other pathogens.