Discovery and SAR of cyclic isothioureas as novel NPY Y1 receptor antagonists

Abstract A class of novel 2-aminobenzothiazoles have been identified as NPY Y 1 antagonists. Various N-heterocyclic substituted aminophenethyl-2-aminobenzothiazole analogs were synthesized to explore the SAR. Isothiourea analogs and ligands with high potency ( K i 30 nM) have been identified.