PERMEABILITY OF CONTRAST MEDIA THROUGH HEMODIALYSIS MEMBRANE

Purpose: To compare the permeability of 10 contrast media (CM) through the hemodialysis membrane.Material and Methods: An experimental model was constructed from clinical hemodialysis equipment. The 10 CM that were used were: diatrizoate, iothalamate, iopami-dol, iohexol, iopromide, ioversol, iomeprol, ioxaglate, iodixanol and iotrolan. They were dissolved into the dialysate. Each solution ran into the blood circuit of the dialyzer at a rate of 200 ml/min and into the dialysate circuit of the dialysis machine at a rate of 500 ml/min. Permeability was expressed as clearance, calculated from the iodine concentration at the afferent and efferent lines of the dialyzer, and from the blood-flow rate.Results: The clearance of all the monomeric CM was superior to that of all the dimeric CM. Values of clearance and molecular weight correlated well.Conclusion: The molecular weight of a contrast medium is the main factor that influences the efficiency of CM removal by hemodialysis.