Images in Clinical Urology Testicular Inflammation as a New Manifestation of IgG4-associated Disease

IgG4-related disease has properties of a systemic disorder but simultaneously is associated with a growing list of organ-specific manifestations including autoimmune pancreatitis, IgG4-associated cholangitis, IgG4-related kidney disease,and IgG4-associated prostatitis. In this study, we present, to the best of our knowledge, the first case of a patient withmultiorgan IgG4-related disease who lost his testes because of IgG4-related testicular inflammation. We postulate thatIgG4-related disease in the urogenital tract is not restricted to IgG4-related kidney disease and prostatitis, but that thisrare disorder may also affect the testis.