Myeloid deprived suppressor cell to mediate the prognostic value of neutrophil for advanced hepatocellular carcinoma patients.

e15597Background: Myeloid Deprived Suppressor Cell (MDSC) has been raised to be a novel target for multiple cancers. However, target agents on MDSC has not displayed promising efficacy. One of the critical reasons shall be less optimal patient selection. In the present study, we aimed to identify optimal advanced hepatocellular carcinoma (aHCC) patients for MDSC targeted therapy. Methods: In the present study, a series of 55 aHCC patients and 20 healthy donors were analyzed investigating frequencies of both monocytic MDSC (M-MDSC; defined as HLA-DRnegCD14posCD33posCD11bpos) and G-MDSC (defined as HLADRnegCD14negCD33posCD11bposCD15pos) in peripheral blood mononuclear cells (PBMC). Then, the association between MDSC and routing blood cell counts were analyzed to identify the possible predictors of MDSC level. Then, the prognostic value of the predictors was determined in retrospective database of 255 aHCC patients. Results: As a result, we found that G-MDSC level (median 5.55%, range 0.60-26.7%) was increas...