Defibrotide for the treatment of PIMS-TS in two pediatric patients.
2020
The pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) is a severe complication of Covid-19. Since impaired coagulation, thrombosis/endotheliitis are suspected pathomechanisms, we treated two patients with defibrotide (DF), a pro-fibrinolytic, antithrombotic, anti-inflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized.
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