Zaltoprofen- â-CD Inclusion Complex for Solubility Enhancement

The aim of present work was to investigate the inclusion complexation of zaltoprofen (ZPF), a water insoluble drug, with â-cyclodextrin (â-CD) in order to improve solubility and dissolution rate of the drug in an attempt to enhance its bioavailability. The complex of ZPF/ â-CD (1:1) was characterized by Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD), Fourier-transform infrared (FT-IR) spectroscopy, solubility and dissolution studies. According to the DSC/PXRD data, no endothermic and characteristic diffraction peaks corresponding to ZPF were observed for the inclusion complex, suggesting that, crystallinity of zaltoprofen was reduced. FTIR study revealed that there was no drugpolymer interaction between ZPF and â-CD. The complex ZPF/â-CD (1:1) exhibited higher dissolution rate than that of pure drug and physical mixture in both pH6.8 and pH7.4 buffer solutions. The aqueous solubility of the complex increased to about 150 and 145 folds in pH6.8 and pH7.4 buffer, respectively with that of pure ZPF. In conclusion, complexation method proved to be the better alternative for the solubility enhancement of poorly water soluble drugs.