Polymer-Mesoporous Silica Nanoparticle Core-Shell Nanofibers as a Dual Drug Delivery System for Guided Tissue Regeneration

Bioactive membranes with growth factors, which mimic the physiological microenvironment of periodontal tissues have shown great potential for guided tissue regeneration (GTR). However, the loss of bioactivity and the uncontrolled drug release in conventional membranes limit their efficacy. In addition, membranes with local infection control ability would provide additional benefits to regeneration. In this work, nano-engineered membranes with growth factor and antibiotic delivery capabilities were developed to achieve dual functions for efficient guided tissue regeneration. Mesoporous silica nanoparticles (MSNs) with large pores with ability to encapsulate and preserve the bioactivity of growth factors were used as the core and antibiotics were loaded in shell nanofibers with coaxial electrospinning. A sustained release behavior of growth factor was observed and the nanoparticle encapsulated core-shell nanofibers shows better ontogenetic regeneration abilities towards bone marrow stromal cells (BMSCs), co...