Análisis de nanoformulaciones de aceite de aguacate para aplicación cutánea

Introduction: vegetable ingredients are increasingly common in skin products. Avocado oil is an ingredient of natural source with various properties on skin. In this work crude avocado oil-loaded nanocapsules were evaluated regarding to its physicochemical stability to obtain a skin delivery formulation with adequate quality. Method: nanoparticles formulations with components variation were evaluated for 2 months. Nanoparticle formulation considered the most stable was further evaluated for 6 months. Furthermore, oxidative stability of nanoencapsulated avocado oil and crude avocado oil was also performed in order to detect any sign of oil oxidation. Results: all formulations had negative zeta potential after 2 months of storage. pH values of nanoparticles ​​remained stable throughout the test. Formulation with the lowest content of ingredients exhibited the highest stability after 2 months of storage. Nanoencapsulated avocado oil and crude avocado oil showed no evidence of oxidation. Conclusions: Aqueous dispersions with the lowest content of ingredients presented the best physicochemical stability. Therefore, we have demonstrated preliminary the feasibility of developing avocado-oil loaded nanocapsules.