Resistance of Veillonella to Hydrosoluble Pristinamycins: A Possible Outer Membrane Barrier Effect

Abstract An in vitro study on 25 Veillonella strains showed a consistent clindamycin susceptibility with resistance to erythromycin and to the hydrosoluble pristinamycins, quinupristin and dalfopristin and its 30:70 combination, the synergistin RP59500. Double erythromycin-clindamycin disk tests did not show any inducible resistance pattern. The addition of 10 or 50 μg/mL of polymyxin B nonapeptide, an outer membrane permeabilizing agent, consistently reduced quinupristin and dalfopristin MICs in most strains. This result suggests that the Veillonella outer membrane may act as a permeability barrier to these antibiotics, as in the case of other Gram-negative bacteria.