Cembrane diterpenoids from the whole plant of Tournefortia sibirica

Abstract Four new cembrane diterpenoids (1–4), along with four known compounds (5–8), were isolated from the whole plant of Tournefortia sibirica L. Their structures of these new compounds were elucidated mainly using NMR, HRESIMS and a modified version of Mosher’s method. The anti-inflammatory effects of the isolated compounds (1–8) were evaluated in terms of inhibition of production of nitric oxide, tumor necrosis factor-α and interleukin-6 in lipopolysaccharide-stimulated RAW264.7 cells.