COMPARISON OF THE PREDICTIVE VALUE OF HSP60 TO OTHER MARKERS OF CARDIOVASCULAR DISEASE AMONG EGYPTIAN PATIENTS WITH TYPE 2 DIABETES

Background: Although heat shock protein 60 (Hsp60) is implicated in the pathogenesis of atherosclerosis, its role in cardiovascular disease is uncertain. The objective of this study was investigate the level of Hsp60 in Egyptian patients with type 2 diabetes mellitus with / without cardiovascular risk factors and compare its level in these patients with some tradational biochemical parameters of cardiovascular complications to elucidate the potential value of Hsp60 in the development of T2DM cardiovascular complications. Methods and Results: 62 diabetic patients with different risks to cardiovascular disease (CVD) and 18 diabetic control patients were included. All groups were age and sex matched. Serum Hsp60 level was determined by Enzyme-linked immunoassay. Results: Hsp60 levels were higher in diabetic patients with diferent risks to CVD complications compared to diabetic group, this increase was independent from other common diagnostic marker for CVD. Hsp60 showed the highest sensitivity compared to other traditional cardiac markers. Conclusion: Presence of Hsp60 with hypertension, dyslipidemia and/or microalbuminuria in diabetic patients was cumulatively associated with greater risk of developing CVD complications. Hsp60 showed the superiority in sensitivity of compared to other traditional biochemical parameters so could serve as an early marker for diagnosis of CVD complications in diabetic patients before it becomes evident.