Beta-cell Function, Self-rated Health, and Lifestyle Habits in 64-Year-Old Swedish Women with Metabolically Healthy Obesity Phenotype.

Background: A subset of obese individuals do not present metabolic abnormalities that commonly define the metabolic syndrome (MetS). This is referred to as a metabolically healthy obese (MHO) phenotype. The aim of the present study was to evaluate the prevalence of the MHO phenotype and its relationship with beta cell dysfunction by measuring C-peptide and proinsulin, anthropometric-, metabolic- and lipid appearance, as well as lifestyle behaviors and self-rated health in a cohort of 64- year-old Swedish women. Methods: The National Cholesterol Education Program definition was used to assess MetS. We defined normal weight as BMI 18.5-24.9 kg/m(2) and obesity as BMI >/=30 kg/m(2) to categorize participants as metabolically healthy normal weight, normal weight obese, and MHO. Results: The MHO phenotype represented 36.3% of obese participants and 16.3% of total participants in the analytic sample. The MHO group were at greater risk of having proinsulin levels >11 pmol/L, indicating impaired beta cell function. Further, homeostatic model assessment for insulin resistance, fasting plasma levels of insulin, and C-peptide showed significant trends, with the MHO phenotype group having intermediate levels. Individuals with the MHO phenotype exhibited lifestyle behaviors such as leisure time physical activity and alcohol intake measures that were intermediate. Conclusion: In this study, we demonstrate that over a third of the obese women in our sample were MHO. Further, women with the MHO phenotype showed intermediate profiles considering beta cell function and insulin resistance, as well as metabolic variables, and tended to rate their general health as worse than otherwise similar individuals of normal weight.