Clinical observation on treatment of newly diagnosed type 2 diabetes with sitagliptin and metformin

Objective To explore the effect of combination of sitagliptin and metformin in treatment of newly diagnosed type 2 diabetes.Methods Sixty cases of newly diagnosed type 2 diabetes were randomly divided into two groups:control group(30 cases)and treatment group(30 cases).The patients in control group were given metformin,those in treatment group(30 cases) received sitagliptin and metformin,the therapies lasted for 12 weeks.The changes in fasting blood-glucose(FBG),2 hours postprandial blood glucose(2 hPG),glycated hemoglobin(HbA1c),body mass index)(BMI),fasting insulin(FINS) and HOMA-insulin resistance(HOMA-IR) were observed in two groups.Results After 12-week treatment,the levels of FBG,2 hPG,HbA1c,BMI showed significant decease(P0.01),but FINS was significantly increased(P0.05).The curative effect of treatment group was better than that of control group,FBG(5.6±1.5) mmol/L vs(7.0±1.8) mmol/L(P0.01);2 hPG(8.2±1.3) mmol/L vs(10.8±2.1) mmol/L(P0.01);HbA1c(6.1±1.2)% vs(7.2±1.0)%(P0.01);FIns(13.2±3.1) mU/L vs(11.5±2.3) mU/L(P0.05).Conclusion Sitagliptin is an effective and safe new medicine in reducing plasma glucose.