General base catalysis and catalysis by nucleophiles in the nitrosation reactions of 1,3-dialkylureas in aqueous-perchloric media

The nitrosation of 1,3-dialkylureas was carried out in the presence of carboxylic acids and halides in an aqueous perchloric medium. The aim of this work was to validate the proposed mechanism for the nitrosation of such substrates. In accordance with the rate limiting step of the proposed mechanism, the protonic transfer to the solvent, basic catalysis and an absence of catalysis by halides should be observed. The Bronsted parameters were determined by basic general catalysis.