The clinical investigation of ischemic tolerance of brain

Objective To explore whether ischemic tolerance exists in patients of cerebral infarction following transient ischemic attacks (TIA). Methods Thirty-eight patients with cerebral infarction following TIA(with TIA group) and 98 patients with cerebral infarction without TIA (without TIA group)were studied. The positive expression rate of CD62P in platelet and the size of cerebral infarction on admission was measured. The scores of activities of daily living were evaluated on admission and after a month. Results The positive expression rate of CD62P in platelet was lower in with TIA group than that in without TIA group [ (4.21 ± 0.43 )% vs (6.01 ± 0.03)%,P< 0.05 ]. The area of cerebral infarction and the scores of activities of daily living were lower in with TIA group than those in without TIA group(P< 0.05 ). Conclusion Cerebral infarction following TIA has ischemic tolerance. Key words: Brain infarction; Platelet activating factor; Brain ischemia