PD24-08 WHICH IS THE BEST TREATMENT FOR HYPOGONADOTROPIC HYPOGONADISM AZOOSPERMIC MEN IN JAPAN?

INTRODUCTION AND OBJECTIVES: The aim of the present study was to evaluate the effect of medical treatment and serum sex steroid levels on sperm retrieval rate in classic Klinefelter cases. METHODS: From June 2002 to September 2013, a total of 89 classic Klinefelter patients whose data had been found were evaluated. Patients age and infertility time were recorded, and serum gonadotropin and sex steroid levels were measured. If serum testosterone level was less than 1.5 ng/ml, hCG treatment was performed for 4 months, and serum hormone levels were measured again. The patients were divided into two groups according to Micro TeSe results and taking medical treatment. Age, infertility time and serum sex steroid hormone level were compared in groups with Student-t test. The effect of medical treatment on sperm retrieval rate was compared by using Pearson Chi square test. Additionally, the effect of male age, infertility time and sex steroid levels on Micro TeSe was evaluated by using correlation test. RESULTS: Patients’ age, infertility time and sex steroid levels are given in the table according Micro Tese results and treatment method. While sperm retrieval rate was 23.9% (11/46) in patients no-performed medical treatment, it was 65.9% (31/47) in medical treatment performed group (Pearson c21⁄420.702, p1⁄40.001). However, there was close and meaningful negative correlation between Micro TeSe results and patients agend infertility time (Age: r1⁄4 -.341, p1⁄40.001; Infertility time: r1⁄4 -.260, p1⁄40.001). CONCLUSIONS: While sperm retrieval rate with micro TeSe was higher in Klinefelter cases after medical treatment and in higher serum testosterone levels, the age of the cases and aging process of the testicular tissue by the year was the most important factors affected sperm extraction in Klinefelter cases.