Retraction Notice to: The Anaphase-Promoting Complex/Cyclosome Is Essential for Entry into Meiotic M-Phase.

(Developmental Cell 36, 94–102; January 11, 2016)This article has been retracted at the request of the authors. Our study reported that APC/C-mediated destruction of protein phosphatase PP6c is a prerequisite for meiotic resumption of immature Xenopus oocytes. Follow-up experiments after publication of the paper performed in our lab revealed severe inconsistencies, and attempts to reproduce the original data were unsuccessful. Confronted with this matter, the first author, Saurav Malhotra, confessed that he had manipulated and falsified reagents and data in the paper. The manipulations and falsifications affect all figures addressing the role of PP6c as the relevant APC/C substrate and all subsequent experiments, including the rescue experiments using PP6c antibodies and the CPEB expression constructs (Figures 2–4 and S2). As the key finding of our study is based on falsified data and is incorrect, the most appropriate course of action is to retract the article. We offer our sincerest apologies to the scientific community for this incident and deeply regret the circumstances.