Massive pericellular collagen deposition in the liver of a young female with severe Crohn's disease

We report a patient with Crohn's disease in whom repeated liver biopsies taken at surgery for the bowel disease showed progressive hepatic fibrosis of an unusual type. Dense collagen was deposited in the perisinusoidal space often surrounding individual hepatocytes. The aetiology and pathogenesis of this abnormality remain speculative.