The Evaluation of the Therapeutic Efficacy and Side Effects of a Macromolecular Dexamethasone Prodrug in the Collagen-Induced Arthritis Mouse Model

Ling Dong Quan,Yijia Zhang,Anand Dusad,Ke Ren,P. Edward Purdue,Steven R. Goldring,Dong Wang

The Evaluation of the Therapeutic Efficacy and Side Effects of a Macromolecular Dexamethasone Prodrug in the Collagen-Induced Arthritis Mouse Model

2016

Ling Dong Quan
Yijia Zhang
Anand Dusad
Ke Ren
P. Edward Purdue
Steven R. Goldring
Dong Wang

Purpose To investigate the efficacy and safety of N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer-dexamethasone conjugate (P-Dex) in the collagen-induced arthritis (CIA) mouse model.

Keywords:

Dexamethasone
Pharmacology
Biochemistry
Methacrylamide
Arthritis
Glucocorticoid
Collagen-induced arthritis
Cancer research
Prodrug
Medicine
pharmacology toxicology
Conjugate

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