SYNTHESIS AND ANTICANCER ACTIVITY OF SOME 1, 3, 4-OXADIAZOLE DERIVATIVES AGAINST EHLIRCH ASCITES CARCINOMA BEARING MICE MODEL

Summary Five Schiff bases of 2-amino-5-aryl-1, 3, 4-Oxadiazole derivatives (a-e) have been synthesized starting from aromatic benzaldehyde. All five compounds have been prepared by using known reaction. The structures of the final compounds were determined by using IR, 1 H NMR Spectroscopy. The evaluation of anticancer activity was done against Ehrlich Ascites Carcinoma bearing albino mice. The synthesized compounds (a-e) were administered intraperitonially at the dose of 25 mg/kg; body weight per day for 7 days after 24 hour of tumor inoculation in mice. The standard compound used was 5-Fluorouracil (20mg/kg; body weight).The drug (a-e) treated groups exhibited decreased in body weight, tumor volume, packed cell volume, viable cell count and increased the tumor inhibition (%), tumor cells inhibition (%), nonviable cell count of EAC tumor bearing mice when compared with the EAC treated control group. The anticancer activity of synthesized (a-e) compounds has not yet been evaluated. The result of the present investigation may encourage us to develop and / improve similar other related compounds and test them for anticancer activity.