Restriction of Dietary Advanced Glycation end Products Induces a Differential Plasma Metabolome and Lipidome Profile.

Scope Diets with low content in advanced glycation endproducts (AGEs) lead to beneficial properties in highly prevalent age-related diseases. To shed light on the mechanisms behind, we analyzed the changes induced by a low AGE dietary intervention in the circulating metabolome. Methods and results To this end, 20 non-diabetic patients undergoing peritoneal dialysis were randomized to continue their usual diet or to one with a low content of AGEs for one month. We then analyzed plasmatic metabolome and lipidomes by liquid-chromatography coupled to mass spectrometry. We also quantified the levels of defined AGE structures by ELISA and by mass-spectrometry. The results show that the low AGE diet impinged significant changes in circulating metabolomes (166 molecules) and lipidomes (91 lipids). Metabolic targets of low-AGE intake included sphingolipid, ether-lipids, and glycerophospholipid metabolism. Further, it reproduced some of the plasma characteristics of healthy aging. Conclusion The finding of common pathways induced by low-AGE diets with previous metabolic traits implicated in aging, insulin resistance, and obesity, suggest the usefulness of the chosen approach and supports the potential extension of this study to other populations. This article is protected by copyright. All rights reserved.