Cyclopropanecarboxamide derivative F crystal form and preparation method thereof

2015 
The invention provides a cyclopropanecarboxamide derivative F crystal form (please see the specification for the formula) in the formula (I). According to the XRPD illustration of the crystal form, diffraction peaks exist when 2Q is equal to 8.717, 9.758, 10.299, 10.8, 12.879, 15.401, 16.64, 16.92, 17.859, 18.759, 19.499, 20.678, 22.841, 23.178, 23.88, 24.479, 25.958, 27.06, 28.039, 29.521 and 31.121, and the error range of the 2Q value is +/-0.2. The cyclopropanecarboxamide derivative F crystal form has good high-temperature stability, high-humidity stability and illumination stability. Moreover, low moisture absorption performance is achieved. The cyclopropanecarboxamide derivative F crystal form can be applied to drugs for treatment or prevention of JAK-participated inflammation and autoimmunity diseases, proliferative diseases, graft rejective reactions and congenital cartilage deformation or diseases caused by IL6 oversecretion, and good bioavailability is achieved. Meanwhile, qualitative and quantitative information is provided, which is of important significance to further studying the curative effect of the solid drugs.
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