Impact of Galactoxyloglucan Coated Iron Oxide Nanoparticles on Reactive Oxygen Species Generation and Magnetic Resonance Imaging for Tumor Management

Cancer therapy triggered by various cell death pathways has attracted widespread attention to improve therapeutic efficiency. Herein, an immunomodulatory polysaccharide (galactoxyloglucan) coated iron oxide nanoconjugate, with a diameter of about 10 nm, is made-up to intracellularly trigger the Fenton reaction and achieve cell death. The nanoconjugate based on iron oxide nanoparticles (PIONPs) exhibits excellent biocompatibility, stability and can be used as an imaging agent. Moreover, importantly it can effectively generate reactive oxygen species (ROS) for tumor eradication with no systemic toxicity. In vitro and In vivo experiments reveal that the PIONPs can intratumorally accumulate and serves as an excellent MRI contrast agent.