Guía de práctica clínica para la tamización de pacientes con riesgo de colonización por Enterobacterales productores de carbapenemasas y el manejo de infecciones causadas por estas bacterias

Carbapenemase-producing Enterobacteriaceae (CPE) infections have increased in recent years. Colombia has become an endemic country for this group of microorganisms and the infections they cause have a serious impact in terms of morbidity and mortality. The early identification of CPE carriers who are admitted to health care institutions as patients is necessary to implement adequate isolation and infection control measures that limit the spread of this type of microorganisms in the hospital setting. Furthermore, treating these infections is a challenging taskdue to the limited therapeutic alternatives available and the fact that there are only quite a few studies proving their effectiveness in this setting. Taking this into account, the objective of this work is to develop a clinical practice guideline (CPG) for the screening of patients at risk of CPE colonization and for the management of inpatients with suspected or confirmed infections caused by this type of enterobacteriaceae  by means of a CPGs adaptation process based on the ADAPTE methodology. With this purpose in mind, evidence-informed recommendations for the screening and timely identification of CPE carriers admitted to hospitals are made, as well as for the adequate pharmacological management of CPE infections in this setting.