Calcium overload and trivalent metal ATP complex-induced carcinogenesis

The effects of calcium overload on carcinogenesis induced by trivalent metal ATP complexes were studied on an animal model. The different stages oftumor development show the involment of intracellular calcium homeostasis. Ultimately, the tumor growth or its inhibition by necrosis depends on factors affecting the calcium overload. The ligand ATP alone does not induce tumors but may have an inhibition in necrotic tumors with very low or nil evolution. The chronologic events of this carcinogenesis is discussed by consideration of ionic factors (calcium, magnesium and phosphorus), as well as histological modifications as spleen hypertrophy and tissular hydration.