Ambroxol hydrochloride atomization inhalant, and preparation method and application thereof
2013
The invention provides an ambroxol hydrochloride atomization inhalant and a preparation method and application thereof. The ambroxol hydrochloride atomization inhalant uses injection water as a solvent and contains ambroxol hydrochloride with a concentration of 7.5 mg/ml and a pharmaceutically acceptable carrier with a concentration of 18 to 28 mg/ml; the carrier comprises a pH value stabilizing agent which is one or more selected from the group consisting of sodium pyrosulfite, sodium hydrosulphite and sodium hydrogen sulfite. The preparation method comprises the following steps: weighing ambroxol hydrochloride and the pharmaceutically acceptable carrier, adding a proper amount of injection water to dissolve ambroxol hydrochloride and the pharmaceutically acceptable carrier, carrying out cooling, then adjusting a pH value by using the pH value stabilizing agent containing sodium pyrosulfite, sodium hydrosulphite and/or sodium hydrogen sulfite and adding water until a desired total amount is almost obtained; then carrying out full stirring with medicinal carbon, carrying out filtering to remove carbon and adding water until the desired total amount is obtained; carrying out filtering with a microfiltration membrane; and filling each bottle with 2 ml, 4ml, 10 ml or 20 ml of the atomization inhalant, then introducing nitrogen and carrying out autoclaved sterilization. The invention further relates to application of the atomization inhalant in preparation of drugs used for treating diseases of the respiratory system.
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