Toll like receptor 1 polymorphisms and susceptibility to invasive candidiasis.

Invasive candidiasis is a severe systemic fungal infection with Candida spp. affecting immunocompromised hosts, which is responsible for the highest mortality rate of all nosocomial infections. Although several clinical predisposing factors are known, the individual risk for developing invasive candidiasis varies significantly. Recognition of fungi such as Candida albicans is mediated through receptors of the innate immune system, such as Toll-like receptors (TLRs), that in turn activate innate immune system and antifungal defense.