Clinical implications of aneuploid cyto genetic profiles in adult acute leukemia

In a series of 170 adult patients with acute leukemia, sequential cytogenetic studies were conducted during a period which included either the initial and, at times, the terminal phase of the disease, or the relapse and remission phases. On the basis of morphological similarities in the karyotype changes, the patients carrying aneuploid clones were categorized into several profiles of aneuploidy. Analysis of the survival times determined from the time of diagnosis suggested that some of these abnormal cytogenetic profiles may have definite clinical implications.